For example, the semicolon (";") and equals ("=") reserved characters are often used to delimit parameters and parameter values applicable to that segment. The comma (",") reserved character is often used for similar purposes. For example, one URI producer might use a segment such as "name;v=1.1" to indicate a reference to version 1.1 of "name", whereas another might use a segment such as "name,1.1" to indicate the same.
http://www.ietf.org/rfc/rfc3986.txt
EDIT: This RFC is for URIs and your question was about URLs. URLs are generally considered a subset of URIs, but according to this SO answer, that might be open to debate. http://stackoverflow.com/questions/176264/whats-the-differen...
http://www.theonion.com/articles/scientific-community-baffle...
/articles/slug,id/
*valid == conforming to spec.
Commas should not be used in URLs because they are so frequently used as delimiters in other scenarios. That's not to say that it can't work (so I'm sure there are some URLs with commas), but according to that RFC we shouldn't use them. Any URL with commas in it would be in violation of that spec. But hey, this is the web, we like to break specs all the time! ;-) It's my impression that this is more for sanity reasons than technical limitations.