The Grugq wrote a post [1] discussing TrueCrypt alternatives back in October of last year. It also mentions tc-play and cryptsetup, but additionally mentions tomb [2], which looks very interesting to me.

But while I once wrote for my mom a document with step-by-step instructions on how to create and use a TrueCrypt volume to keep some work documents secured, I don't see any alternative in either post that is going to be as accessible to normal folks (like her) as TrueCrypt.

[1] http://grugq.tumblr.com/post/60464139008/alternative-truecry... [2] http://www.dyne.org/software/tomb/