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Put it in .htaccess. No restarts needed.

That's correct - I was thinking of using an Apache VirtualHost file. (Isn't using the .htaccess file slower(?) than using the VirtualHost file?)

It is slower, since .htaccess is parsed on every request. (However, it is probably faster than routing through PHP code.)

You can reload Apache without a restart (apache2/httpd graceful/reload depending on your distro).