Where did the money go? Did you turn it into assets? If so then you may want to simply sell all or part of what you have.
If you did not turn your income into assets but it has all burned up see what you can do in terms of documenting your business related costs over that time. Conditional on the IRS agreeing with all this you could then make them a proposal on how much you'll pay month-to-month.
If you feel that that is not going to be a possibility you might end up having to declare bankruptcy. That's a real pain in the ass, but if you have no assets and no income that's probably where you're headed. If you have assets or income then likely you can make a deal. If you have assets that are somehow worth something to a bank you could possibly use these as collateral for a loan.
Best of luck!