Cue, the home lab for quantified self
cue.me
cue.me
As useful as self-diagnostic equipment cam be, the more we can measure, the more likely people with unwarranted health worries can run to the doctor with "My X level is off by 5% says my $150 uncalibrated thing".
I get the feeling that this falls somewhere between very useful (like glucose level to a diabetic), and negatively helpful (a misinterpreted level that causes unhelpful behavior).
It's not easy to interpret these numbers and you have to have quite a deep understanding of statistics, i.e you can be in the normal range and be sick, and you can be outside and be healthy. Type i/ii errors, precision, accuracy, calibration etc etc. I'm sure hackernews knows what's up I'm sure.
It's said about 90% of all diagnosis can be made only on taking the history. Tests are normally only done to assure, quantify, guide treatment etc.
* Testosterone: I have no idea why you would be interested in measuring this at home and I strongly suspect this could lead to misguided treatment with severe side effects.
* Inflamation: Probably a C-reactive protein. Pretty much useless on it's own.
* Fertility: Not sure exactly what they measure but I guess LSH/FSH. This job can be more easily done with a thermometer.
* Vitamin D: If you are worried, get it checked ONCE. No need to check day to day. If you take a supplement, your body will regulate the rest.
* Influenza: Again, not sure what they are testing and why you would want to do this as there's no specific treatment. When you do a test, always reflect what you will use the result for.
IMHO this device lacks the "test" that actually would be useful, like * glucose * maybe TSH * your weight * your activity level * your caloric intake * your sleep
Because these are things that actually mean a lot to your general wellbeing.
[not native english speaker disclaimer]
I, for one, would not shed a tear if the role of human diagnostician is replaced by computer systems with far more raw data to work with than was ever before possible.
Watching a family member with an extended illness, I came to the conclusion that we would be better off if doctors stopped thinking of themselves AS healthcare and were instead the human face of delivering healthcare.
I believe you are right. I'm sorry you had bad experiences. All physicians are different.
I believe all patients should take an active role in their healthcare (that includes smoking, diet and exercise). My point is only that sometimes a misappropriate amount of time can be wasted on very very subtle differences and we forget the big picture.
Computer diagnostics is the future. I'm on HN for a reason.
> It's not easy to interpret these numbers and you have to have quite a deep understanding of statistics, i.e you can be in the normal range and be sick, and you can be outside and be healthy. Type i/ii errors, precision, accuracy, calibration etc etc. I'm sure hackernews knows what's up I'm sure.
Doctors mathematical abilities are less than legendary. I would rather own the raw data and choose my own method of analysis.
> It's said about 90% of all diagnosis can be made only on taking the history. Tests are normally only done to assure, quantify, guide treatment etc.
This is an argument for this device. Having something at home that you can use to test on regular basis will give you the rich historical data you need to make a better diagnosis.
The goal is to discover a problem before you are sick enough to feel the need for constant testing.
The tests seem to interest different groups. I imagine these are the first of many different types of tests planned. You are right about glucose, they probably didn't go there yet because of the competition.
A lot of you arguments are "if you want this tested go to the doctor." Really? do you know what a pain in the ass it is to go to the doctor? First I have to take of work, then I have to wait for him. Then I have to talk to a doctor or nurse about my concerns only to have them act like they are unimportant. Of course there is the cost. Honestly as a consumer I find going to the doctor to be one of the most annoying experiences.
I'll stay at home if I can
However, medicine needs to develop and home diagnosis and early detection along with encouraging and active lifestyle is the future. There are some tough challenges ahead. Maybe this is a step in the right direction, but as I said, I'm not 100% convinced by this device as i feel it kind of misses the point and focuses on some random fairly unimportant tests.
Well let's say your CRP went to a 100, your nose is running and you have a a cough... what would you do?
> Doctors mathematical abilities are less than legendary.
True that :-)
Testosterone: saliva sample, free testosterone
Fertility: blood sample, Luteinizing Hormone (LH)
Inflammation: blood sample, C Reactive Protien
Vitamin D: blood sample, 25(OH)D Vitamin D
Flu: nostril swab, Influenza A
any further thoughts?
Testosterone: still not sure why you would like to test this regularly at home. But I'm not an endocrinologist.
CRP: Very unspecfic marker of inflamation.
LH: I guess I was wrong and this could be quite useful http://www.ncbi.nlm.nih.gov/pubmed/950047
Vitamin D: Severe depletion can give you unspecific symptoms so it's not bad. There's just no need to test it more than once really. If you are depleted just take supplements.
Flu: Still beats me why this would be useful other than general interest (which sometimes is enough I guess).
Babies
My concern with Cue is both medical and practical. I'm a Rheumatologist, so I deal with CRP/Inflammation a lot. Its an incredibly non specific test, with large variability. It does have a utility in monitoring disease activity but usually in conjunction with a physical exam and other testing. A positive/elevated test with poor specificity has a poor positive predictive value. So my practical concern is, lets say you use cue to check your CRP, and its elevated. Okay, so what? What information did one just gain from this device. I think the same can be said from the other tests.
In the words of Horace Dediu, I'm not sure what the "Job To Be Done" is for Cue. What is someone hiring Cue to do for them? I really don't know.
bleh
No, I'm not going to preorder a product now that ships sometime in 2015. Not even for a 50% discount.
Agreed, but unfortunately the business environment has changed. The cost to start a business has decreased so much it is much harder to convince investors to drop a few million into something when there are so many cheaper alternatives.
Additionally everyone is doing preorders, and you are not, you are probably at an disadvantage.
> And if you need additional funding to make your vision happen, sites like kickstarter offer a clean and generally well understood way of making that happen.
They do not allow medical devices.
thank you, i was wrong there.
Pre-orders can be an excellent form of market research.
UPDATE: from the FAQ:
"Cartridges are single-use and disposable. To enhance user safety and hygiene as well as minimalize contamination of samples, the Sample Wand permanently locks inside the cartridge and is disposed of with the cartridge." (...) "A 5-pack of inflammation vitamin D, fertility, testosterone, cartridges costs $20/pack. A 3-pack of flu cartridges costs $30."
Definitively not the everyday tracking thing seen on the video.
You can track 5 key health molecules: inflammation, vitamin D, fertility, influenza, and testosterone in just minutes, at home.
I was trying to figure out what the device can tell you about yourself, and it appears it can't tell you very much at present. Also, these things aren't 'molecules'.
As an MVP this is exciting stuff! In a few years we might have something that is actually useful.
I'd actually benefit from being able to monitor my testosterone levels, so this interests me.
How would my world come to an end without it? I often wonder if the ADHD you get from availability of all this data subtracts more than a product adds.
"Be your most motivated". How did our ancestors do it? Keeping things simple is as important as having the power promised by information. We still fail at the simple things, while getting distracted by complicated things.
"Add a sample". A sample of what? I'm also curious about how they measure how well you sleep and how they achieved wireless charging.
I kept imagining this "simple and easy to use sample wand" as a massive self-administered spinal tap, sort of like those water extractors from the 'Tank Girl' movie.
Sort of funny when you're to the point that marketing talk makes you assume the very worst possible scenario.
I like the concept here, but the mobile integration seems wholly arbitrary and shoe-horned. Yes, we want everything mobile, but if I'm sticking my blood sample in this thing I don't know why I couldn't just get an email or have it connect directly to my device.
Like others here have said, I would mostly want guarantees about the efficacy of the device wrt results. And I'd want a whole bunch more than fertility (is this just a LH measurement), "inflammation," vitamin D and the flu. Perhaps that's a phase two?
And to echo others, please stop scrolljacking. Thanks.
And there's such a disparity of metrics here that you're getting a pretty incomplete health picture unless you want to know if you're infertile or have the flu.
How accurate is Cue?
We use rigorous, gold-standard internal testing and validation techniques to evaluate the performance of Cue. We cannot make any specific claims on the performance of the device, because it is not yet cleared by the FDA. However, we will not release Cue until it has met our own internal performance standards.
I confess I'm dying to know how "Inflammation is elevated, recover with a green smoothie" is going to get past the FDA.
What is the measure of inflammation? Are they really measuring ESR, CRP, and PV? If so, how would you predict that recovery would occur via the medicinal green smoothie, as opposed to knowing that there are early signs of, say, psoriatic arthritis?
Kudos if they can pull that off.
I wish you produce it as soon as possible and get my money.
Gattaca anyone?
This is why I think you counterpoint is not exactly spot-on. On the other hand I share your disagreement with Gattaca-inspired fear mongering: if chemical analysis of your tissues can provide useful information for recruitment we should embrace it. Interviewing is flawed and hard as it is, so any improvement should be welcome. My fear would be that chemical composition turns out completely useless like many other simplistic solutions to complex issues around selecting the right humans for any job.
I disagree.
There are no fields in which poor health is an advantage. So, that idea extrapolated, their are no jobs which wouldn't benefit in some way from having the most healthy staff possible.
I'm of the opinion that it is the job of recruitment staff to secure employees who are capable of doing the job that's asked of them, capable of advancement, and capable of a degree of amiability which will allow them to work well with the other parts of the system.
If chemical analysis were to be used normally in the course of recruitment, it'd no longer be a game of determining if the candidate was capable of the task, but rather a min-maxing of attributes which would be expected to produce a company with the results desired.
Simply put : I, too, fear that chemical composition is far too simple a criteria to judge a possible (human) candidate on.
"Cue Inc. will be conducting tests and collecting information and data from a number of individuals to ultimately support submission to FDA of a pre-market notification 510(k). We hope that you will consider voluntarily participating in these tests. These tests are exempt for Investigational Device Exemption requirements because the testing (a) is noninvasive; (b) does not require an invasive sampling procedure that presents significant risk; (c) does not by design or intention introduce energy into a subject, and (d) is not used as a diagnostic procedure without confirmation of the diagnosis by another, medically established diagnostic product or procedure."
I'm curious what they'll cite for predicate devices.