So it doesn't surprise me that he said that to a room full of young wantrepreneurs ready to kill themselves working 100-hour weeks in hopes of an acquihire (probably by Facebook). It also doesn't surprise me that he blew $100 million on the good cause of helping his home school district -- looked great in the press and continued the narrative he wanted for himself. It manipulates large numbers of people in a way he wants them manipulated. This is his medium.
I wish him the best -- and that maybe he learns a little bit. I know that probably sounds condescending, but Zuck is at a huge disadvantage compared to the rest of us, similar to that disadvantage faced by rockstars: he's at the top of his game. The job has to be a killer, but as far as social feedback goes, he's unlikely to screw it up. When I was 25, if I went in and told my boss he was an idiot, I would lose my job. People would ask me what my problem was, and I'd have a good chance to do some introspection. He has no similar natural social limitations. So he can keep on saying and doing things like this without the opportunity for introspection most of us would have.
That sucks.
EDIT: Removed the first clause, which seemed to be giving some people problems.