MIT scholar fights malaria with magnets
bostonglobe.com
bostonglobe.com
Fighting malaria is something I'm interested in pursuing, but my background is heavily in the computer science arena. How do I go about finding out enough about malaria to be able to actually contribute to the problem? (And I don't mean merely writing a check to the Anti Malaria Foundation or whatever.)
Read as much as you can: http://scholar.google.com/scholar?q=malaria
A lot of mechanical engineers in academia are actually working on (or looking to work on) research that has medical applications, because you can get funding from the NIH. Although academics are technically supposed to be "independent," the funding climate ultimately drives research interests.
> What's that thought process like?
Well, presuming that he was already well aware of the ability to use magnets to move minuscule quantities of iron, it starts out with something like this: http://lmgtfy.com/?q=human+body+iron
Note that it doesn't have to start out with malaria. In fact, you don't have to know anything about human disease when starting out.
"He founded DDG in Cleveland, where he earned his undergraduate degree at Case Western Reserve University. Lewandowski’s cofounder and former faculty adviser, Brian T. Grimberg, is an assistant professor of international health at the university’s medical school, and a specialist in malaria."
What I'd like to see is an open source version of this machine which can be easily reproduced in pure countries.
HOWEVER, smart as it may seem, if I don't see some triple-checked hard-data, it's hard to tell if the magnets approach actually works and here is were professional clinical trials are made. Because in real life it's extremely hard to take say 5.000 blood samples from people who might be infected (e.g. Africans) right down the results, then go to a professional lab and compare the samples. Write down the results, find in which conditions concentration of 'Fe' is high in blood. Probably talking to the IDI[1] would be a nice first step and so on.
The Gates Foundation has been funding development of a very similar technique by another group since 2010: http://www.malariaworld.org/sites/default/files/mwjournal/ar...
It appears to be an active and promising area of research as several other groups have published work back to at least 2008: http://www.nature.com/srep/2013/130312/srep01431/full/srep01... (2013) http://www.malariajournal.com/content/9/1/207 (2010) http://www.cell.com/biophysj/abstract/S0006-3495(08)70272-8 (2008)
During the time when I lived in Africa I was treated for "presumed" malaria on several occasions despite taking preventative medication. The key is "presumed" because my fever cycled at night (the best time to draw blood for the existing test) they could never actually show that I had the disease because at night the lab was closed.
Malaria is an awful disease and the ability to treat earlier and possibly prevent the spread is fantastic news.