Any python developer will tell you they have accidentally indented or un-indented some code, and that error took hours to find
It comes up, sure, but no more frequently than any other syntax error in a different language and there are usually dead giveaways indicating what happened. Most IDEs/editors have options to view whitespace characters, so if you're worried about encountering a bug from this you can always enable that feature.
It's really a non-issue.