I was always an extrovert before I started freelancing, and enjoyed meeting people and going to events/parties. Unfortunately, after a decade of working alone from my home office, I've slowly become an introvert, and am decidedly uncomfortable in social situations. I'm attempting to change this by forcing myself to go to various meetups, but it's hard.
Working from home has been a great benefit, and has helped my wife and I raise our children in the manner we had hoped. But I've definitely paid a price for 10 years of freelancing from home, by myself.
I'd recommend scheduling frequent social events on your calendar from the very start.