Simple (very common example):
<pre>
.some-css-rule {
padding-left:50px;
padding-right:50px;
}
</pre>
Say I want to edit those two numbers. With multi-cursors, it's as simple as select one number, hitting a button that causes the other number to be selected, then writing the new value.
Now, after I wrote it, I realize I forgot to put a space after the colon, and want to change the formatting. No problem - I just make the change to the first line, and the next line follows.
Same as macros? Kind of. But let's say I make a mistake in the macro, e.g., I move the cursor left to the beggining of the line letter-by-letter instead of hitting "home", which is a killer for a macro since each line is a different length. (this is a contrived example a real vim'er will never do, but there are plenty of real examples of 'oops forgot about that' things when recording macros).
Anyway, when I run my macro, suddenly things won't work, and then undoing and starting the re-record process takes time. But if I'm doing this with mulitple-cursors, I see right away, visually that something's wrong, and it's easy to fix - I just hit "home" after moving the cursor left.
And note - this is a drop-dead-simple use case that happens 10's of times a day for any css programmer. Similarly, most programmers will run into cases where they have two similar if blocks one after another, or two similar "except" blocks, and so on.
And that's not even going into lots of other, very powerful cases, like taking a function that gets a list of paramaters, and being able to easily manipulate these paramaters, e.g. given "foo(a, b, c, d, e)", I can easily multi-cursor all the commas, then copy all the params, then paste them after the func definition, hit enter, and I've got a list of all the params after the function definition. And this isn't hard, at all! I visually see everything I'm doing as I do it, and if something goes wrong, I fix it on the spot.
I could ramble more about this, but I think I've either convinced you I'm crazy, or at least to try multi-cursors out :)