Looks like a great library... It would be intriguing to try to use something like DatomicScript for the app state of an Om application.
(Edit: Read in a separate blog post that the author of DatomicScript is thinking about this already)
At the end of the day though, I still think someone (smarter than me) needs to figure out the full end-to-end solution for datomic+clojurescript, with both client and server elements.
The core question: Does it make sense to map datomic to a REST API on the server, then consume the REST on the client? Or, does it make more sense to build something more clojure-like for the client-server interface, and remove REST from the equation entirely?