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I'm curious if they tried Cython. I've read that you can achieve up to 35% speedup just by compiling python code, plus you can type pyx file to get near C performance.

I never tried it, this would have been a nice use case.

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We did. We used Cython where we could, but Cython doesn't work with Twisted (or at least inline deferreds, which holy we had everywhere), due to different generator semantics. Edit: in fact, our internal protobuf lib was all generated Cython. We had a code-gen inception.

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