To live forever?
Interesting knowledge will continue to exist into the future for a while. If no one has built a particle accelerator the size of a planet yet by the time I get my PhD in Physics, I'll build one for my dissertation. Then once we find the second and fourth dimensions, we may discover the actual secrets of the universe. Or AI will do it for us.
Ultimately I think the thing to do will be to colonize the universe for humanity. To try and reach the next type on the Kardashev Scale. http://en.wikipedia.org/wiki/Kardashev_scale