I'm a C/C++/Java guy. I didn't find the idea of Lisp or the basic syntax that hard.
Where I ran into trouble was not the strangeness of the syntax, but the sparseness: "It takes a macro to write a decent loop? Isn't that telling you that your basic syntax is ridiculously impoverished?" I mean, yes, you can implement absolutely anything, but in the bare syntax, you're given absolutely nothing.
Second trouble spot: Lack of static types. It makes it hard to reason about a function if I don't know what's passed into it. I have to read the code and guess, from what it does, what the form of the arguments were supposed to be. And every caller has to know it, and to follow it. If they don't, chaos will ensue, unless the function defends itself by checking the arguments. But that means verifying, by examination, that what got passed in is what was expected - not the easiest task.
Now, Lisp people say that this isn't a problem in practice, because as you play with the code, if the wrong thing happens it will throw you into the debugger. But different code paths wind up getting exercised in the wild, and I've spent most of my career in embedded systems. Dropping into a debugger is not an acceptable bug-handling strategy in my world. I'd rather have the compiler catch them.