Any particular chapters that contains the really important lessons?
It's quite a high level book, so doesn't go into anything in TOO much detail, but instead is supposed to give an entrepreneur - even non-technical - a good understanding of most aspects of building a web app (or at least, what that consisted of a few years ago).
The dev chapters probably won't hold much interest to HN visitors (as they'll know much of the advice), but the marketing ones, maybe some of the design ones, might have some new insights if you've been focusing mostly on tech in your day to day work.