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I use the Google Apps/Gmail interface also. I've found that as it has matured over time there are less reasons I would want a desktop client and more reasons for having the portability of a cross platform, location independent web interface.

Gmail is a class act when it comes to web apps.

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I use IMAP on gmail with opera. I need a desktop client, for times when i'm not connected and quickly need to search an old email for some small little detail.

I just use it as an offline backup, and keep it synced.

Google has an offline gmail version in beta. Requires Google Gears (not available for FF3.5, last I checked) but works for Safari.

All my mail is synced locally but I can still use the Gmail interface.

it doesn't sync all your mail.

It is available for Firefox 3.5 and it does sync all your recent mail, including attachments. It uses an automatic, non-configurable heuristic to determine how much mail to sync. I believe mine syncs the past 1 year's.

Me too - using Gmail + Gears w/ Safari 4 Fluid app, and a dock badge 'inbox count' userscript. Google will tell you you can't install gears with safari 4 - but it works.

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