A few years ago I saw a story on BBC suggesting a despairing outlook for people of the Indian subcontinent origin (Indian/Pakistani/Bangladeshi - IPB); it was titled "Asian heart disease gene found". It reported that a significant percentage of IPBs have a gene that regardless of lifestyle and/or dietary choices, will kill them rather early [1]. I have not read the actual, grim study.
For non UK audience: Asian == UK term for people of the Indian subcontinent origin