but what about things like ctrl-s and ctrl-b in Google Docs? Those are handy and I rarely save a page or create a bookmark by hotkey.
I can think of two ways to solve this: (1) decouple apps from the browser frame or (2) use a special modifier key for app shortcuts (perhaps re-use the Windows key, e.g. Win+Ctrl+S).
"An exception may be if your site provides specific functionality such as in a drawing application. Even in this case it is best to provide shortcuts as an option the user has to turn on rather than one that is on by default."