I think it's like being a man in an all-girls gathering. You can either be awkward or the center of attention. It depends on your perception and how you would present yourself.
Or you could, say, not radically alter your behavior based on the genders of the people around you.
For an example that plays off the original poster's idea, imagine a group of 6 couples, 5 of which have children, and a single couple that does not. Conversation may drift into parenthood related topics based on the high percentage of parents present. The childless couple can choose their own level of involvement in this conversation, and the two ends of the spectrum are probably awkwardness and center of attention. The center of attention strategy is fairly easy to achieve in this scenario. Profess your ignorance to child rearing strategies, and you will almost instantly be regaled with countless tales from those present...