I don't see why not. When I clock out of work, it all stops. I don't get work email on my personal phone, I sign off IM, etc. I am completely unreachable (except for calls, which nobody ever really does). No matter how stressful the day was, or how much stress is coming up, there's a clear delineation between work and life, and one doesn't bleed into the other.

It has kept me pretty happy with my job for more than a year now, even though I've taken almost no vacation (which is not as bad as it sounds, I work remotely).