Considering that you can convert PHP files to Hack by just changing the opening tag, I think it would be very similar to the way HHVM is used currently.
For that matter, are people mostly using HHVM via fast-cgi?
Although it's not an MVC site, they do a lot of inline HTML ...
You could use a common PHP framework like FuelPHP, Laravel or Kohana. I'm not sure which frameworks are 100% compatible with HHVM, but I think they're all getting quite close to 100% (or may even be at 100% with the 3.0 release). It's fine to mix PHP and Hack in the one project, so you could use a PHP framework and use Hack just for your code.