Descent is the only game that has made me feel slightly nauseous playing on a normal screen (OK what was for the time a super high definition 21" screen)...
Descent was quite immersive even without VR, actually. I remember that I frequently tried looking around corners by bending my neck only to notice that, no, it doesn't work that way.
Although that could also be due to Descent being the first actual 3D game I saw.
Conversely I could play Descent all day long and feel fine, but Doom would make me feel motion sick after a few hours.