The obvious big concern here is comments about minority groups and social justice. Are the 1000+ karma users going to shut down those voices?
And you don't know that it's not going to swing the other way, where people would be more likely to speak out because no one's going to endorse the stock replies - i.e., the exhausting nits picked over this comment: https://news.ycombinator.com/item?id=7418937 wouldn't all be there.
There are a lot of users with > 1000 points.
edit: not one, a few.