I've not found anything in the Node.js world that's as nice as Django's models to sit down with and model the data and relationships required for whatever you need to do and play with it in a REPL as you do so, or kick off an admin config to get the data working before you touch a line of request-handling code. It's a similar story for things that are built on top of django.models, like its auto-admin, or much of the ecosystem of django-* libraries. I couldn't leave django.forms behind, though, so I ported it to JS :)
In terms of your everyday handling HTTP requests, it's much of a muchness. Request objects, response objects, get some data, render a template, you know the drill. It's never going to feel the same as Python & Django, but you can comfortably write the sort of apps you write with Django in it, as long as you're down with the asyncness. If anything, certain parts can be even stronger - Jade templates, IMO, make it even more convenient to to do Django-style template inheritance, while its mixins make it much easier to extract reusable chunks of markup + logic without having to step outside templates. You also have the option to reuse templates - and other pieces which support the whole "isomorphic" thing - on the client side , but that not might be the sort of thing you need to do.
As ever, "it depends".