Well, running the old LucasArts adventures would be easy with ScummVM integrated, but I wonder if they can secure the rights. A promising sign is that Tim Schafer (made a lot of the early adventures) recently went to LucasArts on a mysterious mission (perhaps just a tour!).

It's doable. I have it working on my Mac with a Flightstick Pro. I've never had sound issues, though (it plays through my Roland SC-55mkII and sounds great).