Yes; I've won, and I know (at least) one other person to have done so.
This means that the sum of the top-left square is strictly increasing, and so "eventually" you'll win (assuming you don't fill up the rest of the board before that).
^In this case a "square" seems like it can just be one of the 2x2 ones, but in the original 2D case, this strategy has focus on building up just a single tile (one of the corners), or it doesn't work.