I've done both wine and beer, recently planted my own home vineyard of 650 vines. In my experience, much more can go wrong with wine than beer but both are worth it when you open the first bottle.
Edit: and now that I think about the other things:
Regarding 1 and 2: some hop varities have mildew problems, and bad weather has negative influence on the growth and other things like alpha acid, so bad weather can have quite the impact on hop quality and availability. The 2013 hop harvest in Germany was quite the disaster, apparently. AA% is a lot lower, and young plants of some new breeds got way too much water.