I started new project on Python 3 yesterday and I can say that there hasn't been any problems so far. Libraries I needed to use were compatible with Python 3: toml, markdown and Jinja2. I'm looking forward to use clint for better CLI as well! Everything was solid and production-ready. It's good to know that some really weird things are fixed in new Python. I can't think of any reason not to start new app in Python 3! :)