I quit my second postdoc to launch a nonprofit research institute (we did not get funding, and are retrying later this year). I currently drive for lyft - and make more money than I did as a postdoc, with far fewer hours and better working conditions. This makes economic sense; it's not clear to me that what I was doing as a scientist was really doing society any good, at least as a late night driver I'm 1) giving people what they want and 2) keeping drunk people off the streets (a social good).

My Academic path has been tortured; graduated from a really good undergrad, went to an even better grad school (my cohort is basically placed as faculty at places like Berkeley, Stanford, UCSD, TSRI, etc). But in grad school I lost time cleaning up after an irresponsible grad student (who, btw, is faculty at UW) and only published two papers that aren't flashy but are solid, and in second-tier journals. Did an amazing first postdoc actually possibly helping the world (pushing forward a drug candidate), at a third-tier school - since due to the economic collapse, was hard to get a job/good position in 2009. One publication, second-tier journal. Did a more amazing second "postdoc" (actually hired as a BS biologist, via craigslist) under a nobel laureate, at an institution where publishing isn't a priority, and the resources available are somewhat orthogonal to doing the comprehensive set of experiments necessary to get a cell/nature/science paper. My efforts resulted in improving an enzyme - three times (there are very few people who can claim to have done that even once), again, second-tier journals (two are papers-in-work, even though I've quit, i'm still going over there to get them written up). I'm not really ever going to get a faculty position (tried, two years running). I see crappier postdocs and grad students get their run, but you know what? I don't care anymore.