to me, hq4x looks better every time.
However, if you're looking at in the case of an SNES emulator or something.. then hq4x seems like the best choice. It keeps true to the original pixel art, while appearing significantly better.
Video of Ours vs HQ4X. Ours seems to have a slight advantage to my eyes, admittedly it is a personal preference. Text has a distinct advantage on HQ4X but Mario and Yoshi look better even if less "accurate". https://research.microsoft.com/en-us/um/people/kopf/pixelart...