If it was easy to guess the next big thing everybody would do it ;-) A 5-10 year horizon is a very long time in computing years. Look back ten years. How many people were accurately guessing the current environment? How many of the big-things now even existed ten years ago?
When I look back at my career I can't point to a single instance of seeing the next-big-thing.
I can point to lots of great things that have happened because I'm continually poking at new ideas, new processes and new bits of tech. So I'm ready to take advantage when one of those does become the next-big-thing.
So yeah. Take a look at JavaScript and the node.js world. Or robotics. Or architecture as code - or whatever. But for god's sake don't bet your career on it in five years time. Explore lots of things. Find stuff you're good at and enjoy. Be ready for when one of those starts turning into the next big thing.