Should I give 2 weeks notice before I quit?

Only when you hold the position of governor. jk.

If you ever want to be hired again and your current boss is going to be on your resume and gets called for a reference it might hurt you.

Personally, I think that unless the situation is absolutely untenable that two weeks notice is a very reasonable thing to do, especially since in most companies they'll wave your obligation to work and will just pay you the two weeks on the spot.

That way you've done the right thing and your employer doesn't have to worry about having somebody walking around that they know is going to leave anyway.