Take health care technology for example. At the end of the day electronic medical records are just getting data in/out of a system. The Net, or the web, is great at this. You can make this adequately secure and distributable and scalable across the globe with little or no setup expense.
The key is getting the good-old-boys to except and institute change, and this requires a large effort in educating.
Then if you want to share data across multiple organizations it's an even higher level of complexity. Industry organizations like HL7, HITSP, IHE, and CCHIT are doing good work to decrease interoperability costs. But we're still far from being able to build plug-and-play systems across the whole industry. The US has no central registry of healthcare provider organizations, so in general if you need data on a particular patient you won't even know who to query. And to even be allowed to electronically connect to another organization you need to have a legal contract in place first, either directly or through an umbrella organization.
The good-old-boys network isn't (much) of a problem in healthcare informatics. The real problems are irreducible complexity and legal / political issues.
This is a great start-up website opportunity (like AutoTrader.com), but I've heard (anecdotally of course) that legal pitfalls abound.