The role of the TLR-4 and TLR-9 agonists; Are they essentially acting as adjuvants for your vaccine when delivered in conjunction with the peptide on the surface of the same microsphere?

Also, did you consider using nanospheres? Why PLGA?

EDIT: This is the bit I want some clarification on, from your white paper:

>These microspheres make the very small targets look large and threatening to the immune system, provoking an immune response after a single dose

EDIT2: Got my answer in the white paper, yes they are adjuvants. Still would like to know why PLGA and what the mechanism of how they appear more "threatening" is.