Taleb's favorite topic is the "black swan event" which is something that the normal distribution, and the idea of standard deviation, don't model that well. In a normal distribution very extreme events should only happen once in the lifetime of several universes. Of course assuming variation inline with a Gaussian process is at the heart of how the Black-Sholes model calculates risk/volatility/etc.
Benoit Mandelbrot argued that financial markets follow a distribution much more similar to the Cauchy distribution (specifically the Levy distribution) rather than a Gaussian. The problem of course is that the Cauchy distribution is pathological in that it doesn't have a mean or variance, you can calculate similar properties for it (location and scale), but it doesn't obey the central limit theorem so in practice it can be very strange to work with.
The normal distribution is fantastic in that it does appear frequently in nature, is very well behaved, and has been extensively studied. However a great amount of future progress is going to come from wrestling with more challenging distributions, and paying more attention to when assumptions of normality need to be questioned. Of course one of the challenges of this is that the normal distribution is baked into a very large number of our existing statistical tools.