I would say no.
Yes, I realize this would still be susceptible to coercion of the humans involved, and other issues, but it could be a building block of some degree of NSA-proofing.
I'm still not sure how my motherboard detects if my case is open...
Full disk encryption TrueCrypt/BitLocker/FileVault can act as countermeasures[2] and modern versions of OSX don't allow DMA from the login screen anymore.
[1] http://www.breaknenter.org/2012/02/adventures-with-daisy-in-...
[2] http://www.researchgate.net/publication/49277520_Cold_Boot_M...