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Yes. If you're already using NX there's nothing to see here.

NX has a "rootless" mode, and a "desktop" mode. xpra has only the "rootless" mode.

That's just not true anymore. You can get a desktop mode by running Xephir inside xpra.

Bah now we're into semantics, but say you're running xpra on display :1. Running an Xnest or Xephyr inside that can't re-use the :1 display. Further, you can run multiple Xnests/Xephyrs inside an xpra session.

I stand by my statement that xpra has only a "rootless" mode, but I will agree that with Xephyr (which is a less-sucky Xnest), there is less of a difference anymore.

It may not matter to you, but xpra feels a lot more light-weight than NX. Installing/using xpra feels like tmux or ssh. NX feels like an enterprise software suite.

It definitely matters. I've always struggled with NX. VNC is easier, but slower.