Using escrow for selling a website?

I have not but I would imagine that it is safe for the seller only if the escrow service is legit and takes measures to protect you.

I have been reading this blog for a while and it seems like the guy has had experience buying and selling website so I would suggest trying to get into contact with him:

http://selfmademinds.com/

I've purchased (literally) millions of dollars worth of websites via escrow.com -- from sites as cheap as $5k each, to sites as expensive as $500,000 each.

I've never had an issue and you can always get someone on the phone if the automated system isn't adequate for a hiccup during the transaction.

I have no affiliation, just a happy customer.