Quick! What's 392 * 7374?
99.9% of people on the planet need pen and paper to figure out the answer. Our oh-so-adaptable brains can't seem to make a few neurons available for simple math. Heck, our brains can't store more than 7-9 items in working memory.
We're mostly unaware of our limitations because everyone else is similarly hobbled. But when we figure out a way to improve human minds, it will be a bigger game changer than anything that has come before.