From then on it depends on how many you want, and if you can find an assembly house that will take a tiny order for (say) 1000 of them. Even in large runs I can't see it costing less than $1000, partly due to the FPGA on the board. Handcrafted aluminium and leather cases are also likely make up several hundred dollars of the price. That case looks particularly resistant to mass-production.
It sounds like the design of the case will be changed if these are going to hit larger scale production, so I don't think that's going to be an issue. It will still likely be expensive though, unless you do a very large run of them.
That being said, I think it's worth it. I can't think of a single laptop which I'd actually love to use forever, or at least until it's so old that it becomes utterly unusable. The only thing that prevents me from declaring this one as the one I'd like is that OpenBSD is a bit shaky on that architecture IIRC.