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Not necessarily: http://clojure.org/clojureclr http://clojure.org/clojurescript

Implementations already exist for the CLR as well as Python, C, Scheme, and of course JavaScript. LLVM appears to be in the thinking stage still: https://github.com/halgari/clojure-metal

To be fair, nothing but JVM and JavaScript are more than just prototypes.

That's not true. In fact, the CLR port has been around and up to date for years and before ClojureScript.

It's used by no one.

You're not only wrong, but incapable of knowing that.

The only dependency to the JVM would be the advantage of integrating with the Java ecosystem.

When compiling Clojure to native code, you won't be able to use Java libraries, unless the native compiler can also generate native code for .class files.

True, but a Clojure-to-native compiler would be able to use native libraries, which isn't exactely in short supply either.

You are right, the main problem being that those native libraries don't know anything about GC and you are forced to create some form of FFI.