You may say: but they have mobile apps? But so do a lot of other companies that don't have 1000 engineers. You need a few really great mobile devs to build great mobile apps, again based on my experience.
I think what has happened for them is that their structure isn't that good and they have scaled too fast (and in this process they have hired a lot of B and C people that aren't that good). It's a least my conclusion based on the limited information I know about them.
There are a few projects that would be well known (Storm, Kestrel, Bootstrap, FlockDB). Although I'm 100% if they were created at Twitter or just hired in.
(I suspect the write load is rather different - the figures I can find for Plurk suggest 8 billion messages in total - Twitter writes half a billion a day.)