I like how it comes out when there is writing in the margins or the in the magazine example, but for a pure textblock it just seems to be a huge amount of wasted space at the bottom of the page and even on the sides.
After all, paper (and PDF) is cheap. It is better to maximise readability than paper-cost-per-word.
I can see one reason which could have historic reasons. When you flip the pages with your hands, they will wear out more on the outer horizontal margins. If you make that margin wider there is less chance of corrupting the printed content. However that would not apply to online pages.
(Both of which also explain why the outer margins are larger than the inner margins.)