One way you could hinder them is geometrically increasing cost of registering additional domains from existing accounts.
Examples:
- Adam wants to set up his personal site. It costs him X to register.
- Bob wants to set up his personal site, and 3 hobby sites. It costs him X + 2X + 4X + 8X = 15X or (2^4 - 1)X.
- Carl the domain squatter wants to register 100 domains. It costs him (2^100 - 1)X. This could be defeated by changing Carl's business name, or other details, which creates extra hassles for him.
Edit: Didn't know that registering new accounts is near 0 effort. Guess that nixes this idea.