In addition to this being potentially more secure, another benefit is that I can specify that KeePass open certain sites in a non-default web browser. I prefer not to log into some sites/accounts using my primary web browser, and KeePass helps me to avoid this. If I were to use a solution like LastPass for all my password management, I would need to pause and recall which browser I use to log into a site/account. But with KeePass, I just mindlessly Alt-Tab, Ctrl-F, Ctrl-C, and Ctrl-U.