I'm fascinated by the A16Z investment strategy. It looks like they will put in any kind of money into companies deemed as winners (GitHub, Oculus), with some small investments thrown in here and there just so they're still considered a VC and not a private equity fund of sorts. I think it's going to work very well for them in the long term, and possibly change the investment landscape for future VC funds.
Either you go huge and buy a stake in the winners at all costs, or you go wide and super early like YC. It does leave a large seed/series A financing gap someone will need to close, and I suspect their returns won't be as stellar as those in the extreme ends of companies financing.