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This approach seems roughly similar to what Sangamo Genetics has been trying for HIV - with some recent success - http://www.aidsmeds.com/articles/Sangamo_genetics_1667_24579...

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Um, actually, on the other hand - re: Sangamo Genetics: http://seekingalpha.com/article/1705622-sangamo-a-fiery-biot...

Yikes!

Zinc finger nucleases are effectively obsolete; CRISPR systems do the same thing, but you don't have to develop custom proteins- just supply the approprately synthesized complementary DNA.

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