There is an unimaginable amount of suffering in this world. Around 150,000 people die each day. About 5 million children die each year. Millions of people are maimed or killed by accident, disease, and violence. Considering this man's talents, I would much rather live in a world where he devoted himself to solving important problems. I realize he wouldn't be as happy, but the expected value in lives saved is quite high.
Before anyone accuses me of hypocrisy: I follow my own advice. I've chosen a career geared toward maximizing my benefit to others, not my own happiness. This quote from Circular Altruism[1] reflects my views:
You know what? This isn't about your feelings. A human life, with all its joys and all its pains, adding up over the course of decades, is worth far more than your brain's feelings of comfort or discomfort with a plan. Does computing the expected utility feel too cold-blooded for your taste? Well, that feeling isn't even a feather in the scales, when a life is at stake. Just shut up and multiply.
If enough people choose to do this, who knows what might happen? Maybe one day humanity will have its shit together.