.NET uses 16-bit characters, but you can use the System.Globalization.StringInfo class to iterate through a string one Unicode character at a time, index into strings by Unicode character, etc. The API's a bit awkward, but it works.
IIRC, Cocoa is one of the very few frameworks/languages/whatever which provides APIs for manipulating and iterating on grapheme clusters out of the box. And provides a page explaining some of the unicode concepts and how they map to NSString: https://developer.apple.com/library/mac/documentation/Cocoa/...