I said tricky, not impossible but I will, even though I'm not sure I'm really qualified to talk about these languages for one thing and for another, I think that these sort of comparisons are pretty pointless to begin with. Also I'm not sure where you are exactly going with your comment.
Lisp + Scheme: I mean if nothing else, people have been trying to make them fast for the last more than half of century. Plus AFAIK most Lisp meta-programming code is generated during compile time through macros not during run-time.
Dylan: I don't really know anything about Dylan but it seems to have come out of Apple and CMU, so there's that. Plus it seems to be just a Lisp dialect.
Smalltalk: You consider Smalltalk fast? Lol.